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Golgicide A

Cat. No. 3584

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Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Biological Activity

Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data

M.Wt:

284.3

Formula:

C₁₇H₁₄F₂N₂

Solubility:

Soluble to 50 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

1139889-93-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157.

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Keywords: Golgicide A, supplier, potent, specific, reversible, inhibitors, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange