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PD 153035 hydrochloride

Cat. No. 1037

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Alternative Name: ZM 252868

Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC₅₀ of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:

396.67

Formula:

C₁₆H₁₄BrN₃O₂.HCl

Solubility:

Soluble to 10 mM in DMSO with gentle warming

Storage:

Store at RT

CAS No:

153436-54-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093. PMID: 8066447.

Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267. PMID: 8568816.

Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099. PMID: 9815602.

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