R&D Systems Inc. Tocris Bioscience Boston Biochem

PD 153035 hydrochloride

Cat. No. 1037

PD 153035 hydrochloride C16H14BrN3O2.HCl [183322-45-4]

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Alternative Name: ZM 252868

Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
396.67
Formula:
C16H14BrN3O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
183322-45-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093. PMID: 8066447.

Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267. PMID: 8568816.

Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099. PMID: 9815602.

If you know of a relevant citation for this product please let us know.

Keywords: PD 153035 hydrochloride, supplier, EGFR-kinase, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, PD153035, hydrochloride, AstraZeneca, ZM252868

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