C 021 dihydrochloride

Cat. No. 3581

C 021 dihydrochloride C27H41N5O2.2HCl [864289-85-0]

Price and Availability

For C 021 dihydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride

Biological Activity

Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64. PMID: 19081254.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: C 021 dihydrochloride, supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists

Quick Order

Find multiple products by catalog number

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request a copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Poster

'New Therapies, Challenges, and Breakthroughs in Asthma' highlights key pathways and new therapies used to treat asthma, including those currently in clinical development.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

New Product Guide


Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area


Potent prostacyclin (PGI2) analog

S 18886

Potent thromboxane A2 (TP) antagonist


Potent Smo antagonist

ONO 8130

EP1 receptor antagonist

TC-G 1008

Potent and selective GPR39 agonist

Ro 1138452 hydrochloride

Selective prostacyclin IP receptor antagonist

JNJ 27141491

Potent and selective human CCR2 antagonist

TY 52156

S1P3 receptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events


Neuroscience 2015

October 17-21, 2015

Chicago, IL