R&D Systems Inc. Tocris Bioscience Boston Biochem

C 021 dihydrochloride

Cat. No. 3581

C 021 dihydrochloride C27H41N5O2.2HCl [864289-85-0]

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Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride

Biological Activity

Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Technical Data

M.Wt:
540.57
Formula:
C27H41N5O2.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
864289-85-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64. PMID: 19081254.

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Keywords: C 021 dihydrochloride, supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists

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