LY 225910

Cat. No. 1018

LY 225910 C27H24BrN3O2 [133040-77-4]

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Chemical Name: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline

Biological Activity

Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M.Wt:
502.41
Formula:
C27H24BrN3O2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
133040-77-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Yu et al (1991) Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 34 1505. PMID: 2016728.

Suman-Chauhan et al (1996) The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376. Regul.Pept. 65 37. PMID: 8876034.

If you know of a relevant citation for this product please let us know.

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Keywords: LY 225910, supplier, Potent, CCK2, antagonists, Cholecystokinin2, Receptors, LY225910, Tocris Bioscience, CCK2 Receptor Antagonists

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