R&D Systems Inc. Tocris Bioscience Boston Biochem

LY 225910

Cat. No. 1018

LY 225910 C27H24BrN3O2 [133040-77-4]

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Chemical Name: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline

Biological Activity

Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M.Wt:
502.41
Formula:
C27H24BrN3O2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
133040-77-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Yu et al (1991) Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 34 1505. PMID: 2016728.

Suman-Chauhan et al (1996) The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [3H]PD140376. Regul.Pept. 65 37. PMID: 8876034.

If you know of a relevant citation for this product please let us know.

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Keywords: LY 225910, supplier, Potent, CCK2, antagonists, Cholecystokinin2, Receptors, LY225910

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