AS 605240

Cat. No. 3578

AS 605240 C12H7N3O2S [648450-29-7]

Price and Availability

For AS 605240 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

Biological Activity

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Technical Data

M.Wt:
257.27
Formula:
C12H7N3O2S
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
648450-29-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Camps et al (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nature Med. 11 936.

Wang et al (2009) Phosphoinositide 3-kinase γ inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem.Biophys.Res.Comm. 386 569.

Peng et al (2010) Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J.Pharmacol.Exp.Ther. 332 46. PMID: 19828878.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: AS 605240, supplier, AS605240, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, Potent, selective, inhibitors, inositol, lipids, signalling, signaling, orally, active, ATP-competitive, Tocris Bioscience, PI 3-kinase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

New Products in this Area

Prostratin

PKC activator; also NF-κB activator

TBCA

Selective CK2 inhibitor

MSC 2032964A

Potent and selective ASK1 inhibitor; orally bioavailable

CW 008

PKA signaling activator; promotes osteogenesis from hMSCs

PF 06447475

Potent LRRK2 inhibitor; neuroprotective

AMG PERK 44

Potent and selective PERK inhibitor; orally bioavailable

CGP 60474

Potent dual cdk1/cdk2 inhibitor

CGP 74514 dihydrochloride

Potent cdk1 inhibitor

KG 5

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Nilvadipine

Syk kinase inhibitor; inhibits Aβ production

Centrinone B

High affinity and selective PLK4 inhibitor

HTH 01-015

Potent and selective NUAK1 inhibitor

Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

OSU 03012

PDK1 inhibitor; inhibits Akt signaling

SR 7826

Potent and selective LIMK inhibitor; antitumor

Mps BAY 2a

Potent and selective Mps1 kinase inhibitor

NG 25

TGF-β-activated kinase (TAK1) inhibitor

MI 14

Potent and selective PI 4-kinase IIIβ inhibitor

CTA 056

ITK inhibitor

AZD 1480

Potent and selective JAK2 inhibitor; antiangiogenic

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.