R&D Systems Inc. Tocris Bioscience Boston Biochem

RuBi-Glutamate

Cat. No. 3574

RuBi-Glutamate C28H32N5O4PRu.2NaPF6

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Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt

Biological Activity

Ruthenium-bipyridine-trimethylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Has high quantum efficiency and can be used at low concentrations, partly avoiding blockade of GABAergic transmission seen with other caged glutamate compounds. Displays high spatial resolution and generates excitatory responses in individual dendritic spines with physiological kinetics.

Licensing Information

Sold under licence from Columbia University

Technical Data

M.Wt:
970.54
Formula:
C28H32N5O4PRu.2NaPF6
Solubility:
Soluble to 20 mM in water
Storage:
Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Fino et al (2009) RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines. Front.Neural Circuits 3 1. PMID: 19506708.

Salierno et al (2010) A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J.Inorg.Biochem. 104 418. PMID: 20060592.

If you know of a relevant citation for this product please let us know.

Keywords: RuBi-Glutamate, supplier, Caged, Glutamate, mGluR, iGluR, Receptors, agonists, ionotropic, metabotropic

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