R&D Systems Inc. Tocris Bioscience Boston Biochem

(S)-WAY 100135 dihydrochloride

Cat. No. 1253

(S)-WAY 100135 dihydrochloride C24H33N3O2.2HCl [149007-54-5]

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Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride

Biological Activity

Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.

Licensing Information

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814

Technical Data

M.Wt:
468.47
Formula:
C24H33N3O2.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonication
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
149007-54-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Cliffe et al (1993) (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J.Med.Chem. 36 1509. PMID: 8496920.

Fletcher et al (1993) WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur.J.Pharmacol. 237 283. PMID: 8365456.

Fletcher et al (1993) Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 14 41. PMID: 8122313.

Rodgers and Cole (1994) Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 261 321. PMID: 7813555.

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Keywords: (S)-WAY 100135 dihydrochloride, supplier, Potent, selective, 5-HT1A, antagonist, Serotonin, Receptors, (S)-WAY100135, dihydrochloride

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