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(S)-WAY 100135 dihydrochloride

Cat. No. 1253

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Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride

Biological Activity

Potent, selective 5-HT_1A receptor antagonist (IC₅₀ = 15 nM). Selective over 5-HT_1B, _1C, ₂,α₁, α₂ and D₂ receptors (IC₅₀ > 1000 nM). Centrally active on systemic administration.

Licensing Information

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814

Technical Data

M.Wt:

468.47

Formula:

C₂₄H₃₃N₃O₂.2HCl

Solubility:

Soluble to 10 mM in water with gentle warming

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

149007-54-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Cliffe et al (1993) (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. J.Med.Chem. 36 1509. PMID: 8496920.

Fletcher et al (1993) WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. Eur.J.Pharmacol. 237 283. PMID: 8365456.

Fletcher et al (1993) Silent 5-HT_1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 14 41. PMID: 8122313.

Rodgers and Cole (1994) Anxiolytic-like effect of (S)-WAY 100135, a 5-HT_1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 261 321. PMID: 7813555.

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