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Bretazenil

Cat No. 3568

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Alternative Name: Ro 16-6028

Chemical Name: (13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo [1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester

Biological Activity

Partial agonist at the GABA_A benzodiazepine site (EC₅₀ = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.

Technical Data

M.Wt:

418.28

Formula:

C₁₉H₂₀BrN₃O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

[84379-13-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Puia et al (1992) Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at g-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology 89 3620. Rundfeldt et al (1995) Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 275 693. Munro et al (2008) Comparison of the novel subtype-selective GABA_A receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain. J.Pharmacol.Exp.Ther. 327 969.

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