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1-EBIO

Cat. No. 1041

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Chemical Name: 1-Ethyl-2-benzimidazolinone

Biological Activity

Activator of epithelial K_Ca channels, stimulates a large and sustained trans-epithelial Cl^- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.

Technical Data

M.Wt:

162.19

Formula:

C₉H₁₀N₂O

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

10045-45-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Devor et al (1996) Modulation of Cl^- secretion by benzimidazolones. I. Direct activation of a Ca²⁺ - dependent K⁺ channel. Am.J.Physiol. 271 L775. PMID: 8944721.

Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial K_Ca channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 379 151. PMID: 10497901.

Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 146 487. PMID: 16056232.

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