R&D Systems Inc. Tocris Bioscience Boston Biochem

Tacrine hydrochloride

Cat. No. 0965

Tacrine hydrochloride C13H14N2.HCl [1684-40-8]

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Chemical Name: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride

Biological Activity

Potent cholinesterase inhibitor, a cognition enhancer in vivo.

Technical Data

M.Wt:
234.73
Formula:
C13H14N2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
1684-40-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 9199.

Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269. PMID: 6994999.

Freeman and Dawson (1991) Tacrine: a pharmacological review. Prog.Neurobiol. 36 257. PMID: 1714613.

Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137. PMID: 8558423.

Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology 38 181. PMID: 10193909.

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Keywords: Tacrine hydrochloride, supplier, Cholinesterase, inhibitor, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic

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