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Diazoxide

Cat. No. 0964

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Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Biological Activity

Antihypertensive, activates ATP-dependent K⁺ channels (K_ir6). Induces activation of PKCε, an intermediate in the opening of mitoK_ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Technical Data

M.Wt:

230.67

Formula:

C₈H₇ClN₂O₂S

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

364-98-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 3051.

Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K⁺ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493. PMID: 2431383.

Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409. PMID: 1302270.

Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral K_ATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059. PMID: 17043673.

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Keywords: Diazoxide, supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier

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