Cat. No. 0964
Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothi
Biological ActivityAntihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 3051.
Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493. PMID: 2431383.
Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409. PMID: 1302270.
Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059. PMID: 17043673.
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Keywords: Diazoxide, supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier
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