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SCH 23390 hydrochloride

Cat. No. 0925

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Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Biological Activity

Potent dopamine receptor antagonist (K_i values are 0.2 nM and 0.3 nM at D₁ and D₅ receptor sub-types respectively). Also an agonist at 5-HT_1C and 5-HT_2C receptors in vitro (K_i values are 6.3 nM and 9.3 nM respectively).

Technical Data

M.Wt:

324.24

Formula:

C₁₇H₁₈ClNO.HCl

Solubility:

Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

125941-87-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Briggs et al (1991) Activation of the 5-HT_1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. PMID: 1687364.

Bourne et al (2001) SCH 23390: The first selective dopamine D₁-like receptor antagonist. CNS Drug Rev. 7 399. PMID: 11830757.

Millan et al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin_2C receptors. Psychopharmacology 156 58. PMID: 11465634.

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Keywords: SCH 23390 hydrochloride, supplier, 5-HT2C, agonists, potent, D1-like, antagonists, selective, Serotonin, Receptors, Dopamine, D1, D5, dopaminergic, SCH23390, hydrochloride

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