R&D Systems Inc. Tocris Bioscience Boston Biochem

SCH 23390 hydrochloride

Cat. No. 0925

SCH 23390 hydrochloride C17H18ClNO.HCl [125941-87-9]

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Alternative Name: (R)-(+)-SCH 23390 hydrochloride

Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Biological Activity

Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).

Technical Data

M.Wt:
324.24
Formula:
C17H18ClNO.HCl
Solubility:
Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
125941-87-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. PMID: 1687364.

Bourne et al (2001) SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7 399. PMID: 11830757.

Millan et al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors. Psychopharmacology 156 58. PMID: 11465634.

If you know of a relevant citation for this product please let us know.

Keywords: SCH 23390 hydrochloride, supplier, 5-HT2C, agonists, potent, D1-like, antagonists, selective, Serotonin, Receptors, Dopamine, D1, D5, dopaminergic, SCH23390, hydrochloride

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