SCH 23390 hydrochloride

Cat. No. 0925

SCH 23390 hydrochloride C17H18ClNO.HCl [125941-87-9]

Price and Availability

For SCH 23390 hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: (R)-(+)-SCH 23390 hydrochloride

Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Biological Activity

Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

Technical Data

Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038. PMID: 1687364.

Bourne et al (2001) SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7 399. PMID: 11830757.

Millan et al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors. Psychopharmacology 156 58. PMID: 11465634.

Kuzhikandathil and Oxford (2002) Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 62 119. PMID: 12065762.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: SCH 23390 hydrochloride, supplier, 5-HT2C, agonists, potent, D1-like, antagonists, selective, Serotonin, Receptors, Dopamine, D1, D5, dopaminergic, SCH23390, hydrochloride, D1 and D5 Receptor Antagonists

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Updated in 2015, this guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Dopamine Review

Dopamine Receptors Scientific Review

Written by Phillip G. Strange and revised by Kim Neve. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity. Request copy today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

'Antidepressants - Current and Future Targets'. Updated in 2015, highlights the presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Updated in 2014 - this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. Request copy or view PDF today.

divider line

New Products in this Area


High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2015

ASCB 2015

December 12 - 16, 2015

San Diego, CA