Cat. No. 3540

Orlistat C29H53NO5 [96829-58-2]

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Chemical Name: N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

Biological Activity

Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A2, liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G1/S boundary in vitro. Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Hadvary et al (1991) The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J.Biol.Chem. 266 2021. PMID: 1899234.

Kridel et al (2004) Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64 2070. PMID: 15026345.

Enc et al (2008) Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am.J.Physiol.Gastrointest.Liver Physiol. 296 G482. PMID: 19109408.

If you know of a relevant citation for this product please let us know.

Keywords: Orlistat, supplier, Fatty, acid, synthases, inhibits, inhibitors, pancreatic, gastric, carboxylester, lipases, Pancreatic, antiobesity, antihypercholesterolemic, antihypercholesterolaemic, activity, Synthases, Esterases, FAS, FASN

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