R&D Systems Inc. Tocris Bioscience Boston Biochem

L-741,742 hydrochloride

Cat. No. 1004

L-741,742 hydrochloride C23H25N2ClO.HCl [874882-93-6]

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Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride

Biological Activity

A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M.Wt:
417.38
Formula:
C23H25N2ClO.HCl
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at RT
CAS No:
874882-93-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J. Med. Chem. 39 1943. PMID: 8642551.

Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J.Med.Chem. 40 2374. PMID: 9240352.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: L-741,742 hydrochloride, supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L741742

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