endo-IWR 1Cat No.
3532
|
Price and Availability |
|
Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4 ,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
|
Biological Activity
Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Chen et al (2008) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100. Lu et al (2009) Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 19 3825.If you know of a useful citation for this product please let us know.
Keywords: endo-IWR 1, wnt, signaling, signalling, inhibitors, axin, axin2, stabilizer, stabiliser
Buy Now / Print Quote
Find multiple products by catalog number
Print Quote Facility
Order via your purchasing department
It's now even easier to place orders via your purchasing department.
Simply add a product to your cart & click on the "Print Quote" button.
Cancer Research Guide
Highlights over 400 products for cancer research. Request a copy or view PDF today.
Signal Transduction Guide
A collection of more than 600 products for signal transduction research. View PDF today.
New Products in this Area
Axin stabilizer; promotes β-catenin phosphorylation
IWP 2Wnt production inhibitor; inactivates porcn
PNU 74654β-catenin binder; inhibits wnt signaling
New Product Guide
Highlights over 250 new products added in 2009/10. Request a copy or view PDF today.