Cat. No. 0994
Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Biological Activity5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. (S)-(-)-Pindolol (Cat. No. 1060) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 7597.
Blin et al (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol.Pharmacol. 44 1094. PMID: 7903415.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.
Clifford et al (1998) Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo. Br.J.Pharmacol. 124 206. PMID: 9630361.
Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449. PMID: 9504386.
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Keywords: Pindolol, supplier, 5-HT1A/1B, antagonists, β3-adrenoceptor, β3-adrenergic, b3-adrenoceptor, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B
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