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Pindolol

Cat. No. 0994

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Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

Biological Activity

5-HT_1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β₃-adrenoceptors. (S)-(-)-Pindolol (Cat. No. 1060) also available.

Technical Data

M.Wt:

248.32

Formula:

C₁₄H₂₀N₂O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

13523-86-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

S-enantiomer Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 7597.

Blin et al (1993) Structural and conformational features determining selective signal transduction in the β₃-adrenergic receptor. Mol.Pharmacol. 44 1094. PMID: 7903415.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.

Clifford et al (1998) Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT_1A autoreceptor in vivo. Br.J.Pharmacol. 124 206. PMID: 9630361.

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT_1A receptors in the rat brain. Br.J.Pharmacol. 123 449. PMID: 9504386.

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Keywords: Pindolol, supplier, 5-HT1A/1B, antagonists, β3-adrenoceptor, β3-adrenergic, b3-adrenoceptor, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B

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7-TM Receptor Signaling

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'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy