Cat. No. 3509
Chemical Name: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Biological ActivityPan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rinkevich et al (2007) Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi. PLoS Biology. 5 e71. PMID: 17341137.
Germain et al (2009) Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 16 479. PMID: 19477412.
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Keywords: BMS 493, supplier, BMS493, retinoic, acid, receptors, agonists, RAR, agonists, inverse, pan-RAR
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