Cat. No. 3508
Alternative Name: LG 1506
Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Biological ActivitySelective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Michellys et al (2003) Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 46 2683. PMID: 12801232.
Leibowitz et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147 1044. PMID: 16269450.
Pinaire et al (2007) Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 94156. PMID: 17497022.
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Keywords: LG 101506, supplier, LG101506, retinoid, x, receptors, rxr, modulators, rxra, rxrb, rxrg, rxralpha, rxrbeta, rxrgamma, rxrα, rxrβ, rxrγ, LG1506, LG_1506
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