Cat. No. 3508
Alternative Name: LG 1506
Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy
Biological ActivitySelective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Michellys et al (2003) Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 46 2683. PMID: 12801232.
Leibowitz et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147 1044. PMID: 16269450.
Pinaire et al (2007) Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 94156. PMID: 17497022.
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Keywords: LG 101506, supplier, LG101506, retinoid, x, receptors, rxr, modulators, rxra, rxrb, rxrg, rxralpha, rxrbeta, rxrgamma, rxrα, rxrβ, rxrγ, LG1506, LG_1506
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