R&D Systems Inc. Tocris Bioscience Boston Biochem

AM 80

Cat. No. 3507

AM 80 C22H25NO3 [94497-51-5]

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Alternative Name: Tamibarotene

Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid

Biological Activity

Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.

Technical Data

M.Wt:
351.44
Formula:
C22H25NO3
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
94497-51-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182. PMID: 3184125.

Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397. PMID: 17611697.

Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225. PMID: 19182380.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: AM 80, supplier, RARα, RARalpha, agonists, anticancer, Retinoic, Acid, Receptors, AM80

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