R&D Systems Inc. Tocris Bioscience Boston Biochem

BMS 753

Cat. No. 3505

BMS 753 C21H21NO4 [215307-86-1]

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Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid

Biological Activity

RARα-selective agonist (Ki = 2 nM).

Technical Data

M.Wt:
351.4
Formula:
C21H21NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
215307-86-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197.

Dilworth et al (1999) Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 96 1995.

Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519. PMID: 10421757.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: BMS 753, supplier, retinoic, acid, agonists, rara, raralpha, rar-α, selective, BMS753

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