R&D Systems Inc. Tocris Bioscience Boston Biochem

AG 1478 hydrochloride

Cat. No. 1276

AG 1478 hydrochloride C16H14ClN3O2.HCl [170449-18-0]

Price and Availability

For AG 1478 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Tyrphostin AG 1478

Chemical Name: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride

Biological Activity

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 μM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
352.22
Formula:
C16H14ClN3O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
170449-18-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782. PMID: 7892601.

Han et al (1996) Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 56 3859. PMID: 8752145.

Eguchi et al (1998) Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J.Biol.Chem. 273 8890. PMID: 9535870.

Puri and Salgia (2008) Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. J.Carcinog. 7 9. PMID: 19240370.

If you know of a relevant citation for this product please let us know.

Keywords: AG 1478 hydrochloride, supplier, potent, EGFR-kinase, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, AG1478, hydrochloride, Tyrphostin, AstraZeneca

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

PLX 647 dihydrochloride

Potent dual Fms/KIT inhibitor

BMS 599626 dihydrochloride

Potent, selective EGFR and ErbB2 inhibitor

Cyclotraxin B

TrkB receptor antagonist

Sign-up for new product e-alerts
divider line

Tocris Events

Win $1,000 Product Credit

Experimental Biology

Experimental Biology

April 26 - 30, 2014

San Diego CA, USA

Booth Number: 918