(-)-Xestospongin C

Cat. No. 1280

(-)-Xestospongin C C28H50N2O2 [88903-69-9]

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Alternative Name: XeC

Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

Biological Activity

Reported inhibitor of IP3-dependent Ca2+ release. Inhibits bradykinin-induced Ca2+ release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Does not interact with the IP3 binding site. Recently shown to be an ineffective antagonist of IP3-evoked Ca2+ release in IP3 receptor expressing DT40 cells. Cell permeable.

Technical Data

M.Wt:
446.71
Formula:
C28H50N2O2
Solubility:
Soluble to 2 mM in DMSO and to 2 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
88903-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Gafni et al (1997) Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19 723. PMID: 9331361.

Ozaki et al (2002) Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 137 1207. PMID: 12466229.

Dadsetan et al (2008) Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J.Biol.Chem. 283 12512. PMID: 18316371.

Saleem et al (2014) Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor. Br.J.Pharmacol. 171 3298. PMID: 24628114.

If you know of a relevant citation for this product please let us know.

Keywords: (-)-Xestospongin C, supplier, inhibitor, inhibits, IP3-mediated, Ca2+, release, blocks, endoplasmic-reticulum, pump, calcium, channels, XeC

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