R&D Systems Inc. Tocris Bioscience Boston Biochem

(-)-Xestospongin C

Cat. No. 1280

(-)-Xestospongin C C28H50N2O2 [88903-69-9]

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Alternative Name: XeC

Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

Biological Activity

Highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release (IC50 = 358 nM). Does not interact with the IP3 binding site and exhibits high selectivity over ryanodine receptors.

Technical Data

M.Wt:
446.71
Formula:
C28H50N2O2
Solubility:
Soluble to 2 mM in DMSO and to 2 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
88903-69-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Gafni et al (1997) Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19 723. PMID: 9331361.

Wilcox et al (1998) New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. TiPS 19 467. PMID: 9850611.

Ozaki et al (2002) Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 137 1207. PMID: 12466229.

Dadsetan et al (2008) Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J.Biol.Chem. 283 12512. PMID: 18316371.

If you know of a relevant citation for this product please let us know.

Keywords: (-)-Xestospongin C, supplier, inhibitor, inhibits, IP3-mediated, Ca2+, release, blocks, endoplasmic-reticulum, pump, calcium, channels, XeC

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