Cat. No. 1280
Alternative Name: XeC
Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)
Biological ActivityHighly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release (IC50 = 358 nM). Does not interact with the IP3 binding site and exhibits high selectivity over ryanodine receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gafni et al (1997) Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19 723. PMID: 9331361.
Wilcox et al (1998) New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. TiPS 19 467. PMID: 9850611.
Ozaki et al (2002) Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 137 1207. PMID: 12466229.
Dadsetan et al (2008) Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J.Biol.Chem. 283 12512. PMID: 18316371.
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Keywords: (-)-Xestospongin C, supplier, inhibitor, inhibits, IP3-mediated, Ca2+, release, blocks, endoplasmic-reticulum, pump, calcium, channels, XeC
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September 11 - 13, 2014