R&D Systems Inc. Tocris Bioscience Boston Biochem

(-)-Xestospongin C

Cat. No. 1280

(-)-Xestospongin C C28H50N2O2 [88903-69-9]

Price and Availability

For (-)-Xestospongin C pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: XeC

Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine

Biological Activity

Highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release (IC50 = 358 nM). Does not interact with the IP3 binding site and exhibits high selectivity over ryanodine receptors.

Technical Data

M.Wt:
446.71
Formula:
C28H50N2O2
Solubility:
Soluble to 2 mM in DMSO and to 2 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
88903-69-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Gafni et al (1997) Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19 723. PMID: 9331361.

Wilcox et al (1998) New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. TiPS 19 467. PMID: 9850611.

Ozaki et al (2002) Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br.J.Pharmacol. 137 1207. PMID: 12466229.

Dadsetan et al (2008) Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J.Biol.Chem. 283 12512. PMID: 18316371.

If you know of a relevant citation for this product please let us know.

Keywords: (-)-Xestospongin C, supplier, inhibitor, inhibits, IP3-mediated, Ca2+, release, blocks, endoplasmic-reticulum, pump, calcium, channels, XeC

Quick Order

Find multiple products by catalog number

divider line

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

Neuroprotection Poster

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

KN 92

Inactive analog of KN 93. K+ channel (Kv) blocker

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Nicotinic Acetylcholine Receptors 2014

Nicotinic Acetylcholine Receptors 2014

July 23 - 27, 2014

Churchill College, Cambridge, UK