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4-IPP

Cat. No. 3429

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Chemical Name: 4-Iodo-6-phenylpyrimidine

Biological Activity

Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Technical Data

M.Wt:

282.08

Formula:

C₁₀H₇IN₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

41270-96-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253. PMID: 18794110.

If you know of a relevant citation for this product please let us know.

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Keywords: 4-IPP, supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, suicide, substrates, cytokines, 4IPP

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