R&D Systems Inc. Tocris Bioscience Boston Biochem

CP 99994 dihydrochloride

Cat. No. 3417

CP 99994 dihydrochloride C19H24N2O.2HCl [136982-36-0]

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Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]­-2-phenyl-3-piperidinamine dihydrochloride

Biological Activity

High affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
369.33
Formula:
C19H24N2O.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
136982-36-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Shirahase et al (1995) Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2. Br.J.Pharmacol. 115 1215. PMID: 7582548.

Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 301 536. PMID: 11961054.

Lindstrom et al (2007) Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 322 1286. PMID: 17575073.

If you know of a relevant citation for this product please let us know.

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