Cat. No. 1124
Chemical Name: (R)-1,4-Dihydro-2,6-dimethyl-4-(3-n
Biological ActivityL-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; less active enantiomer. (S)-(+)-Niguldipine hydrochloride (Cat. No. 1123) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131. PMID: 2548881.
Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329. PMID: 2555206.
Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601. PMID: 1352973.
Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579. PMID: 7752182.
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Keywords: (R)-(-)-Niguldipine hydrochloride, supplier, Ca2+, channel, blocker, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent
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September 17, 2015