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(R)-(-)-Niguldipine hydrochloride

Cat. No. 1124

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Chemical Name: (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride

Biological Activity

L-type Ca²⁺ channel blocker and α_1A-adrenoceptor antagonist; less active enantiomer. (S)-(+)-Niguldipine hydrochloride (Cat. No. 1123) also available.

Technical Data

M.Wt:

646.18

Formula:

C₃₆H₃₉N₃O₆.HCl

Solubility:

Soluble to 10 mM in water

Storage:

Desiccate at -20°C

CAS No:

113145-70-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

S-enantiomer Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca²⁺ channels and to a subtype of alpha₁-adrenoceptor. Eur.J.Pharmacol. 172 131. PMID: 2548881.

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha_1A-adrenoceptors labeled with [³H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329. PMID: 2555206.

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601. PMID: 1352973.

Wetzel et al (1995) Discovery of alpha_1a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine. J.Med.Chem. 38 1579. PMID: 7752182.

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