R&D Systems Inc. Tocris Bioscience Boston Biochem

Vinorelbine ditartrate

Cat. No. 3401

Vinorelbine ditartrate C45H54N4O8.2C4H6O6 [125317-39-7]

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Alternative Name: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M.Wt:
1079.1
Formula:
C45H54N4O8.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
125317-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475. PMID: 9316630.

Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol.Pharmacol. 60 225. PMID: 11408618.

Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol.Cancer Ther. 2 427. PMID: 12748304.

If you know of a relevant citation for this product please let us know.

Keywords: Vinorelbine ditartrate, supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin

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