Cat. No. 3401
Alternative Name: Navelbine
Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-
Biological ActivitySelective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475. PMID: 9316630.
Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol.Pharmacol. 60 225. PMID: 11408618.
Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol.Cancer Ther. 2 427. PMID: 12748304.
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Keywords: Vinorelbine ditartrate, supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin
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July 23 - 27, 2014
Churchill College, Cambridge, UK