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RuBi-GABA

Cat No. 3400

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Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminob utyric acid ruthenium hexafluorophosphate complex

Biological Activity

Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths and has two-photon uncaging capabilities. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.

Licensing Information

Sold under license from Columbia University; Patent Pending

Technical Data

M.Wt:

922.8

Formula:

C₄₂H₄₀Cl₂N₅O₂PRu

Solubility:

Soluble to 10 mM in water

Storage:

Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882. Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Comm. 7 1752. Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2.

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Keywords: RuBi-GABA, Caged, GABA, GABAA, GABAC, Receptors, GABAB

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