Cat. No. 3400
Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Biological ActivityRuthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.
Licensing InformationSold under license from CHEMCAGE, patent 8063216
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882. PMID: 12537482.
Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2. PMID: 18946542.
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Keywords: RuBi-GABA, supplier, Caged, GABA, GABAA, GABAC, Receptors, GABAB
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