RuBi-GABACat No. 3400 |
Price and Availability |
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Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminob utyric acid ruthenium hexafluorophosphate complex |
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Biological Activity
Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths and has two-photon uncaging capabilities. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.Licensing Information
Sold under license from Columbia University; Patent PendingTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882. Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Comm. 7 1752. Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2.If you know of a useful citation for this product please let us know.
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Keywords: RuBi-GABA, Caged, GABA, GABAA, GABAC, Receptors, GABAB
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2009-10 Catalog
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