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AM 1172

Cat No. 3381

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Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydrox ybenzamide

Biological Activity

Metabolically stable anandamide uptake inhibitor (IC₅₀ = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (K_i = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC₅₀ = 24 μM) and hydrolysis (K_i = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC₅₀ = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC₅₀ values are 189 and 271 nM at CB₂ and CB₁ receptors respectively).

Technical Data

M.Wt:

409.6

Formula:

C₂₇H₃₉NO₂

Solubility:

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[251908-92-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Fegley et al (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA 101 8756. Kaczocha et al (2006) Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 281 9066. Hillard et al (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 33 18.

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Keywords: AM 1172, Anandamide, uptake, inhibitors, AMT, FAAH, inhibitor, CB, receptors, partial, agonists, cannabinoid, fatty, acid, amide, hydrolase, neurotransmitter, transporters, AM1172, cb2r, cb1r

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