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Tenovin-1Cat. No. 3365 |
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Chemical Name: N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide |
Biological Activity
p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.Certificate of Analysis / Safety Data Sheet
References
Lain et al (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454. PMID: 18455128.
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Keywords: Tenovin-1, supplier, activators, p53, transcriptional, activity, Protects, against, MDM2-mediated, degradation, Transcription, Factors, Ligases
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