Cat. No. 3362
Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Biological ActivityRestores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
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For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. PMID: 15998635.
Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. PMID: 16557267.
Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168. PMID: 17485365.
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Keywords: MIRA-1, supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors