R&D Systems Inc. Tocris Bioscience Boston Biochem

MIRA-1

Cat. No. 3362

MIRA-1 C8H9NO4 [72835-26-8]

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Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione

Biological Activity

Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Technical Data

M.Wt:
183.16
Formula:
C8H9NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
72835-26-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. PMID: 15998635.

Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. PMID: 16557267.

Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168. PMID: 17485365.

If you know of a relevant citation for this product please let us know.

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Keywords: MIRA-1, supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors

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