R&D Systems Inc. Tocris Bioscience Boston Biochem

MIRA-1

Cat. No. 3362

MIRA-1 C8H9NO4 [72835-26-8]

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Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione

Biological Activity

Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Technical Data

M.Wt:
183.16
Formula:
C8H9NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
72835-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. PMID: 15998635.

Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. PMID: 16557267.

Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168. PMID: 17485365.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: MIRA-1, supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors

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