Cat. No. 3356
Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride
Biological ActivityCell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
North et al (2000) The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19 1206. PMID: 10713709.
Pluquet et al (2003) The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 278 11879. PMID: 12531896.
Walker et al (2009) WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen. 50 460.
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Keywords: WR 1065, supplier, p53, activators, ROS, scavenger, Apoptosis, Cell, Cycle, Transcription, Factors, reactive, oxygen, species, WR1065
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Induces G2/M cell cycle arrest; anticancer
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October 15, 2013