WR 1065

Cat No. 3356

WR 1065 C5H14N2S.2HCl [14653-77-1]

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Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride

Biological Activity

Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

Technical Data

M.Wt:
207.16
Formula:
C5H14N2S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
[14653-77-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

North et al (2000) The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19 1206. Pluquet et al (2003) The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 278 11879. Walker et al (2009) WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen. 50 460.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Keywords: WR 1065, p53, activators, ROS, scavenger, Apoptosis, Cell, Cycle, Transcription, Factors, reactive, oxygen, species, scavenger, WR1065

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