WR 1065Cat No. 3356 |
Price and Availability |
|
Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride |
|
Biological Activity
Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
North et al (2000) The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 19 1206. Pluquet et al (2003) The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 278 11879. Walker et al (2009) WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen. 50 460.If you know of a useful citation for this product please let us know.
Keywords: WR 1065, p53, activators, ROS, scavenger, Apoptosis, Cell, Cycle, Transcription, Factors, reactive, oxygen, species, scavenger, WR1065
Buy Now / Print Quote
Find multiple products by catalog number
Print Quote Facility
Order via your purchasing department
It's now even easier to place orders via your purchasing department.
Simply add a product to your cart & click on the "Print Quote" button.
Signal Transduction Guide
A collection of more than 600 products for signal transduction research. View PDF today.
Cancer Research Guide
Highlights over 400 products for cancer research. Request a copy or view PDF today.
VEGF Pathway & Anti-Angiogenic Therapy
Written by N. Ferrara & Y. Crawford
A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.
New Products in this Area
Hdm2 inhibitor; activates p53-dependent transcription
SJ 172550MDMX inhibitor. Disrupts MDMX-p53 interaction
INH1Hec1 inhibitor; causes arrest of mitosis
Cyclic Pifithrin-α hydrobromidep53 inhibitor
RSS News Feed
Find out about new products as soon as they go live!
Click on the orange RSS button to read more about our RSS feed and actively opt in.