JNJ 28871063 hydrochloride
Cat. No. 3352
Chemical Name: 5E-4-Amino-6-(4-benzyloxy-3-chlorop
Biological ActivityPotent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271. PMID: 17981994.
Emanuel et al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338. PMID: 17975007.
Guessous et al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217 577.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: JNJ 28871063 hydrochloride, supplier, Potent, ErbB, receptor, family, inhibitors, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, JNJ28871063, hydrochloride
Find multiple products by catalog number
New Products in this Area
Potent c-MET/ALK inhibitorAC 710
Potent and selective PDGFR family inhibitorSPP 86
Potent RET inhibitorSGX 523
Selective and potent c-MET kinase inhibitorNBI 31772
High affinity insulin-like growth factor-I binding protein IGFBP inhibitorAPcK 110
Highly potent HGF/c-MET inhibitor; also AT4 antagonistAEE 788
Potent EGFR and VEGFR inhibitorXL 184
Potent VEGFR inhibitor; also inhibits other RTKs
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.