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Home »
Pharmacology » Ion Channels » Ligand-gated Ion Channels » Glutamate (Ionotropic) Receptors » NMDA Receptors » Ro 8-4304 hydrochloride
Ro 8-4304 hydrochloride
Cat No.
3343
Price and Availability
Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyrid inyl]-2-hydroxypropoxy]benzamide hydrochloride
Biological Activity
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine.Technical Data
M.Wt:406.88
Formula:C21H23FN2O3.HCl
Solubility:Soluble to 10 mM in Water and to 100 mM in DMSO
Purity: >99 %
Storage:Desiccate at RT
CAS No:[195988-65-9]
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch
References
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463. Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17.Keywords: Ro 8-4304 hydrochloride, NR2B, selective, antagonists, NMDA, Receptors, Glutamate, Ionotropic, N-Methyl-D-Aspartate, iGluR, Ro8-4304
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