Ro 8-4304 hydrochloride

Cat No. 3343

Ro 8-4304 hydrochloride C21H23FN2O3.HCl [195988-65-9]

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Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyrid inyl]-2-hydroxypropoxy]benzamide hydrochloride

Biological Activity

NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for NR2B-containing receptors over NR2A-containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine.

Technical Data

M.Wt:
406.88
Formula:
C21H23FN2O3.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
[195988-65-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463. Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17.

If you know of a useful citation for this product please let us know.

View Related Products by Target

Keywords: Ro 8-4304 hydrochloride, NR2B, selective, antagonists, NMDA, Receptors, Glutamate, Ionotropic, N-Methyl-D-Aspartate, iGluR, Ro8-4304

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