Cat. No. 3324
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Biological ActivityGTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252. PMID: 17493865 .
Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444. PMID: 17460038.
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Keywords: QS 11, supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors
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