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BI 78D3

Cat. No. 3314

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Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one

Biological Activity

Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC₅₀ = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

Technical Data

M.Wt:

379.37

Formula:

C₁₃H₉N₅O₅S₂

Solubility:

Soluble to 100 mM in DMSO and to 5 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

883065-90-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Flight (2008) Getting rid of JNK. Nat.Rev.Drug Disc. 7 975.

Haas and Writer (2008) Block JNK at the dock. SCiBX 1 1.

Stebbins et al (2008) Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 105 16809.

If you know of a relevant citation for this product please let us know.

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Keywords: BI 78D3, supplier, Selective, competitive, JNK, inhibitors, MAPK, Signaling, Signalling, c-Jun, N-Terminal, Kinases, SAPKs, Stress-Activated, Protein, Mitogen-Activated, p38, BI78D3

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