R&D Systems Inc. Tocris Bioscience Boston Biochem

Cyclopiazonic acid

Cat. No. 1235

Cyclopiazonic acid C20H20N2O3 [18172-33-3]

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Alternative Name: α-Cyclopiazonic acid

Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

Biological Activity

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.

Technical Data

M.Wt:
336.39
Formula:
C20H20N2O3
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
18172-33-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Plenge-Tellechea et al (1997) On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid. J.Biol.Chem. 272 2794. PMID: 9006919.

Soler et al (1998) Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry 37 4266. PMID: 9521749.

Takemoto et al (1998) Comparison of contractions produced by carbachol, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle. Br.J.Pharmacol. 124 1449. PMID: 9723957.

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Keywords: Cyclopiazonic acid, supplier, Inhibitors, SERCA, ATPase, Ca2+, modulators, Ca2+-ATPase, Signaling, Signalling, Calcium, P-Type, ATPases, Calcium-ATPase, Ion, Transporters, Pumps, α-Cyclopiazonic, acid, alpha-Cyclopiazonic

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