Cat. No. 3304
Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-in
Biological ActivityPotent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697.
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Keywords: SU 16f, supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, Tocris Bioscience, PDGFR Inhibitors
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