Cat. No. 3304
Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-in
Biological ActivityPotent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: SU 16f, supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f
Find multiple products by catalog number
New Products in this Area
Potent PDGFR and VEGFR inhibitorNVP ADW 742
ATP-competitive inhibitor of IGF1RKRCA 0008
Potent Ack1 and ALK dual inhibitor; orally bioavailableDDR1-IN-1 dihydrochloride
Selective DDR1 inhibitorHNGF6A
Humanin analog; increases insulin sensitivityGSK 1838705
Potent and selective IR and IGF1R inhibitor; antitumorSUN 11602
Basic fibroblast growth factor (bFGF) mimetic; neuroprotective
November 15 - 19, 2014
Washington D.C., USA