Cat. No. 3300
Chemical Name: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl
Biological ActivityPotent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sun et al (1999) Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697.
Paterson et al (2004) Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 124 595. PMID: 14871245.
Tanaka et al (2005) FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435 172. PMID: 15889083.
Su et al (2009) Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 41 916. PMID: 18834954.
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Keywords: SU 5402, supplier, Potent, VEGFR, FGFR, inhibitors, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, Fibroblast, SU5402, neural, stem, cells, differentiation, Tocris Bioscience, FGFR Inhibitors
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