Cat. No. 3300
Chemical Name: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl
Biological ActivityPotent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sun et al (1999) Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697.
Paterson et al (2004) Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 124 595. PMID: 14871245.
Tanaka et al (2005) FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435 172. PMID: 15889083.
Su et al (2009) Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 41 916. PMID: 18834954.
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Keywords: SU 5402, supplier, Potent, VEGFR, FGFR, inhibitors, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, Fibroblast, SU5402, neural, stem, cells, differentiation
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