Home » Pharmacology » Enzymes » Transferases » DNA Methyltransferases » RG 108

RG 108

Cat. No. 3295

Price and Availability

For RG 108 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Phthalyl-L-tryptophan

Biological Activity

Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

Technical Data

M.Wt:

334.33

Formula:

C₁₉H₁₄N₂O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

48208-26-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305. PMID: 16024632.

Schirrmacher et al (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 17 261. PMID: 16536454.

Stresemann et al (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 2794. PMID: 16510601.

Liang et al (2010) Butyrate promotes iPS cell generation. J.Biol.Chem. 285 25516. PMID: 20554530.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

DNA Methyltransferases Epigenetics Stem Cell Dedifferentiation

Stem Cells Transferases

Keywords: RG 108, supplier, Non-nucleoside, DNA, methyltransferase, inhibitor, inhibitors, transferases, RG108, inhibits, DNA, methylation, dnmt, epigenetics