Cat. No. 3295
Chemical Name: N-Phthalyl-L-tryptophan
Biological ActivityNon-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305. PMID: 16024632.
Schirrmacher et al (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 17 261. PMID: 16536454.
Stresemann et al (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 2794. PMID: 16510601.
Liang et al (2010) Butyrate promotes iPS cell generation. J.Biol.Chem. 285 25516. PMID: 20554530.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: RG 108, supplier, Non-nucleoside, DNA, methyltransferase, inhibitor, inhibitors, transferases, RG108, inhibits, DNA, methylation, dnmt, epigenetics
Find multiple products by catalog number
New Products in this Area
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorCRID3 sodium salt
Glutathione S-transferase omega 1 (GSTO1) inhibitorUNC 2327
Allosteric inhibitor of PRMT3Furamidine dihydrochloride
Selective PRMT1 inhibitorXY1
Negative control of SGC 707 (Cat. No. 5367)SGC 707
Potent and selective allosteric inhibitor of PRMT3IWP 12
Potent PORCN inhibitor; active in vivoAZD 3988
Potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitorWDR5 0103
WDR5 antagonistUNC 2400
Negative control of UNC 1999 (Cat. No. 4904)UNC 1999
Potent and selective EZH2/EZH1 inhibitorGarcinol
PCAF/p300 inhibitor; anticancer(S)-PFI 2 hydrochloride
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.