Home » Pharmacology » Ion Channels » Ligand-gated Ion Channels » GABA_A and GABA_C Receptors » GABA_C Receptors » TPMPA

TPMPA

Cat. No. 1040

Price and Availability

For TPMPA pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid

Biological Activity

A selective, competitive GABA_C antagonist with only minimal effects on GABA_A and GABA_B receptors (K_b values are 2.1 μM (antagonist), 320 μM (antagonist) and EC₅₀ ~ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors.

Technical Data

M.Wt:

161.14

Formula:

C₆H₁₂NO₂P

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

182485-36-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Murata et al (1996) The first selective antagonist for a GABA_c receptor. Bioorg.Med.Chem.Lett. 6 2073.

Ragozzino et al (1996) Design and in vitro pharmacology of a selective γ-aminobutyric acidc receptor antagonist. Mol.Pharmacol. 50 1024. PMID: 8863850.

Chebib et al (1998) GABA_C receptor antagonists differentiate between human r1 and r2 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 357 227. PMID: 9797041.

Xu et al (2009) The involvement of GABA-C receptors in paired pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons. Exp.Neurol. 216 243. PMID: 19100735.

If you know of a relevant citation for this product please let us know.