Cat. No. 3292

Metyrapone C14H14N2O [54-36-4]

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Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propanone

Biological Activity

Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hays et al (1984) Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyrapone analogues. J.Med.Chem. 27 15. PMID: 6606707.

Asakura and Shichi (1992) Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells. Exp.Eye Res. 55 377. PMID: 1426070.

Park et al (2005) Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4. J.Am.Chem.Soc. 127 13634. PMID: 16190729.

If you know of a relevant citation for this product please let us know.

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Keywords: Metyrapone, supplier, steroid, 11-β, 11-beta, hydroxylase, inhibitors, Cytochrome, P450, CYP11B1, CYP3A4, omega/ω-1, omega-1

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