R&D Systems Inc. Tocris Bioscience Boston Biochem

Metyrapone

Cat. No. 3292

Metyrapone C14H14N2O [54-36-4]

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Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propanone

Biological Activity

Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.

Technical Data

M.Wt:
226.27
Formula:
C14H14N2O
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
54-36-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Hays et al (1984) Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyrapone analogues. J.Med.Chem. 27 15. PMID: 6606707.

Asakura and Shichi (1992) Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells. Exp.Eye Res. 55 377. PMID: 1426070.

Park et al (2005) Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4. J.Am.Chem.Soc. 127 13634. PMID: 16190729.

If you know of a relevant citation for this product please let us know.

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Keywords: Metyrapone, supplier, steroid, 11-β, 11-beta, hydroxylase, inhibitors, Cytochrome, P450, CYP11B1, CYP3A4, omega/ω-1, omega-1

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