Cat. No. 3292
Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propa
Biological ActivityCytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hays et al (1984) Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyrapone analogues. J.Med.Chem. 27 15. PMID: 6606707.
Asakura and Shichi (1992) Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells. Exp.Eye Res. 55 377. PMID: 1426070.
Park et al (2005) Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4. J.Am.Chem.Soc. 127 13634. PMID: 16190729.
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Keywords: Metyrapone, supplier, steroid, 11-β, 11-beta, hydroxylase, inhibitors, Cytochrome, P450, CYP11B1, CYP3A4, omega/ω-1, omega-1
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August 30 - September 4, 2014
Booth Number: 22