Cat. No. 3287
Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazi
Biological ActivityD2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lummis and Baker (1997) Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors. Neuropharmacology 36 665. PMID: 9225292.
Ghelardini et al (2004) Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 50 351. PMID: 15225680.
Satoh et al (2005) The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci. 97 101.
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Keywords: Prochlorperazine dimaleate, supplier, D2, receptor, antagonists, 5-HT3, nAChR, Dopamine, Receptors, serotonin, dopaminergic
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High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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