R&D Systems Inc. Tocris Bioscience Boston Biochem

Prochlorperazine dimaleate

Cat. No. 3287

Prochlorperazine dimaleate C20H24ClN3S.2C4H4O4 [84-02-6]

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Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate

Biological Activity

D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Technical Data

M.Wt:
606.09
Formula:
C20H24ClN3S.2C4H4O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
84-02-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lummis and Baker (1997) Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors. Neuropharmacology 36 665. PMID: 9225292.

Ghelardini et al (2004) Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 50 351. PMID: 15225680.

Satoh et al (2005) The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci. 97 101.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Prochlorperazine dimaleate, supplier, D2, receptor, antagonists, 5-HT3, nAChR, Dopamine, Receptors, serotonin, dopaminergic

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