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6-Chloromelatonin

Cat. No. 0443

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Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity

Potent melatonin agonist (pK_i values are 9.10 and 9.77 for human recombinant MT₁ and MT₂ receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Technical Data

M.Wt:

266.73

Formula:

C₁₃H₁₅ClN₂O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

63762-74-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Safety Data Sheet: View Safety Data Sheet

References

Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633.

Duncan et al (1988) 2-[¹²⁵I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122 1825. PMID: 2834175.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

If you know of a relevant citation for this product please let us know.

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Melatonin Receptors

Keywords: 6-Chloromelatonin, supplier, Melatonin, agonists, MT, Receptors

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