R&D Systems Inc. Tocris Bioscience Boston Biochem

6-Chloromelatonin

Cat. No. 0443

6-Chloromelatonin C13H15ClN2O2 [63762-74-3]

Price and Availability

For 6-Chloromelatonin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity

Potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Technical Data

M.Wt:
266.73
Formula:
C13H15ClN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
63762-74-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633.

Duncan et al (1988) 2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122 1825. PMID: 2834175.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: 6-Chloromelatonin, supplier, Melatonin, agonists, MT, Receptors

Quick Order

Find multiple products by catalog number

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

ONO AE3 208

High affinity and selective EP4 antagonist

TCS 3035

GPR35 agonist

PF 5274857 hydrochloride

Potent and selective smoothened (Smo) receptor antagonist

GSK 137647

Potent and selective FFA4 (GPR120) agonist

AH 7614

Selective FFA4 (GPR120) antagonist

Prosaptide TX14(A)

Potent GPR37 and GPR37L1 agonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Neuroscience 2014

Neuroscience 2014

November 15 - 19, 2014

Washington D.C., USA