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7-Chlorokynurenic acid

Cat. No. 0237

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Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. 7-Chlorokynurenic acid sodium salt (Cat. No. 3697) also available.

Technical Data

M.Wt:

223.62

Formula:

C₁₀H₆CINO₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH

Purity:

>98 %

Storage:

Store at RT

CAS No:

18000-24-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Sodium Salt Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Safety Data Sheet: View Safety Data Sheet

References

Donald et al (1988) Characterization of [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P.

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.U.S.A. 85 6547. PMID: 2842779.

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37. PMID: 7498252.

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839. PMID: 9776380.

If you know of a relevant citation for this product please let us know.

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Keywords: 7-Chlorokynurenic acid, supplier, Potent, competitive, inhibitors, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic

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