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Milnacipran hydrochloride

Cat No. 3286

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Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcycloprop anecarboxamide hydrochloride

Biological Activity

Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC₅₀ values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α₁-adrenergic and 5-HT_2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

Technical Data

M.Wt:

282.81

Formula:

C₁₅H₂₂N₂O.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

[101152-94-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211. Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α₁-adrenergic and serotonergic 5-HT_2A systems. J.Neural.Transm. 107 1345. Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation. Anesth.Analg. 106 1309.

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Keywords: Milnacipran hydrochloride, 5-HT, noradrenaline, reuptake, inhibitors, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine

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