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LY 487379 hydrochloride

Cat No. 3283

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Chemical Name: 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyr idinylmethyl)ethanesulfonamide hydrochloride

Biological Activity

Positive allosteric modulator selective for mGlu₂ receptors. Potentiates glutamate-stimulated [³⁵S]GTPγS binding (EC₅₀ values are 1.7 and > 10 μM for mGlu₂ and mGlu₃ receptors respectively). Devoid of any activity at mGlu₅ and mGlu₇ receptors.

Technical Data

M.Wt:

488.91

Formula:

C₂₁H₁₉F₃N₂O₄S.HCl

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

[353231-17-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Johnson et al (2003) Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,-trifluoroethylsulfonyl)pyrid-3-ylmethyl-amine. J.Med.Chem. 46 3189. Schaffhauser et al (2003) Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol.Pharmacol. 64 798. Poisik et al (2005) Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology 49 57.

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