Cat. No. 3278
Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
Biological ActivityOrally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).
Licensing Information(Sold with the permission of Astellas Pharma Inc.)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265.
Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189.
Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871. PMID: 8904814.
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Keywords: YM 511, supplier, Potent, aromatase, CYP19, inhibitors, Cytochrome, P450, ERR, Estrogen, Receptors, YM511
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