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YM 511

Cat. No. 3278

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Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile

Biological Activity

Orally active, potent aromatase (CYP19) inhibitor (IC₅₀ values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC₅₀ = 0.13 nM).

Licensing Information

(Sold with the permission of Astellas Pharma Inc.)

Technical Data

M.Wt:

354.2

Formula:

C₁₆H₁₂BrN₅

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

148869-05-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265.

Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189.

Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871. PMID: 8904814.

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