Pentamidine isethionate

Cat No. 3277

Pentamidine isethionate C19H24N4O2.2C2H6O4S [140-64-7]

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Chemical Name: 4,4'-(Pentamethylenedioxy)dibenzamidine bis-2-hydroxyethanesulfonate salt

Biological Activity

Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.

Technical Data

M.Wt:
592.68
Formula:
C19H24N4O2.2C2H6O4S
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
[140-64-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J. Neurosci. 12 970. Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299.

If you know of a useful citation for this product please let us know.

Keywords: Pentamidine isethionate, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, Nitric, oxide, Synthases

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