Cat. No. 1110
Chemical Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Biological ActivityPhytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPARγ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 4395.
Akiyama et al (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J.Biol.Chem. 262 5592. PMID: 3106339.
Linassier et al (1990) Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochem.Pharmacol. 39 187. PMID: 2153378.
Migita et al (1994) Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors. J.Immunol. 153 3457. PMID: 7523495.
Dang et al (2003) Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein. J.Biol.Chem. 278 962. PMID: 12421816.
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Keywords: Genistein, supplier, PPARγ, PPARgamma, ligands, estrogen, receptor, EGFR, inhibitors, GPR30, agonists, tyrosine, kinase, Estrogen, Peroxisome, Proliferator-activating, Receptors, PPAR, Epidermal, Growth, Factors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, ER, ERR, GPER
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